Abstrato

Solubility and Dissolution Rate Enhancement of Olmesartan Medoxomil by Solid Dispersion Technique and Development of Orodispersible Tablets

O. Kumar, A. Prameela Rani  and V. Sai Kishore

Solid dispersions were prepared by solvent evaporation method with different carriers such as PVP-K90, mannitol and urea in different proportions. All the solid dispersions prepared were evaluated for saturation solubility study, drug content and for dissolution studies. Among all the formulations prepared, solid dispersions prepared with Olmesartan medoxomil and Urea in 1:3 ratio showed highest drug release in 60 minutes. To study the influence of superdisintegrants on the performance of Olmesartan Medoxomil Orodispersible Tablets, a set of three formulations (F10, F11 and F12) were prepared using three different superdisintegrants viz, Sodium starchglycolate (5%), Croscarmalose sodium (5%), Crospovidone (5%) respectively. The dispersible tablets of Olmesartan medoxomil were evaluated for various parameters. Based on the dissolution rate, superdisintegrants can be rated as Sodium Starch Glycolate < Croscarmalose sodium < Crospovidone. The formulation prepared with Crospovidone was offered relatively rapid release of Olmesartan Medoxomil when compared with other superdisintegrants used in this investigation. The dissolution rate followed first-order kinetics. The drug release from optimized formulations was found be quite stable while stored at 25 ± 2ºC, 60 ± 5% RH and at 40 ± 2 ºC, 75 ± 5% RH.