Abstrato

Formulation and Evaluation of Propranolol Hydrochloride Microsphers.

Kanaka Durga Vikash Guntiboyina, Sanjay P Umachigi, Prasanth VV, Abhishek Sharma, Rinku Mathappan, and Sam T Mathew

Six formulations of Propranolol Hydrochloride loaded microspheres were prepared by non-aqueous emulsification-solvent evaporation technique.The percentageyield of the microspheres varied from 75.33 ± 0.006 and 92.21 ± 0.003. The entrapment efficiency of Propranolol Hydrochloride microspheres were ranged between 79.7 ± 0.02 and 85.87 ± 0.03 %. It was reported that the encapsulation efficiency depends on the solubility of the drug in the solvent.The mean particle size of the prepared formulation ranged from 256.56 ± 0.07 and 382.77 ± 0.05μm. The drug content of the prepared formulation ranged between 76.19 ± 2.5 and 87.74 ± 3.1%. The swelling indices of the microspheres were high (up to 0.89 ± 0.02 for F4) and varied between the formulations.The maximum in vitro release was evaluated to be 96.55 % over a period of 14 h for formulation F4. The in vitro drug release increased in the following order: F1< F6< F3< F5< F2< F4.Formulations F6 provided good fit to the Higuchi model and the remaining formulations showed the best fit to the Korsmeyer-Peppas model.Scanning electron micrographs of selected formulation indicated that the microspheres were discrete, uniform and spherical with a smooth surface. During at the end of accelerated stability studies the tested formulation (F4) showed non-significantly different drug content, entrapment efficiency and in vitro drug release from that observed at the beginning of the study. No color changes were also observed during the study period.