Abstrato

Design and Development of Fast Dissolving Tablets of Ibuprofen

V Sai Kishore, D Gowtham Kumar, B Sudheer and M Sandeep

The aim of the present investigation was to develop fast dissolving tablets of Ibuprofen, an NSAID drug used for the treatment of arthritis. Due to its low solubility, gastric irritation and its short biological half-life of 2 hours, fast dissolving tablets of Ibuprofen were prepared using superdisintegrants in order to improve the dissolution rate, thereby the absorption and to reduce gastric irritation. The influence of concentration of the sodium starch glycolate was studied by a set of four formulations (F1, F2, F3, F4) with concentrations of sodium starch glycolate viz, 2%, 3%, 4% & 5%w/w respectively. Also the influence of various superdisintegrants was studied by a set of three formulations (F4, F5 and F6) with three superdisintegrants viz, Sodium starch glycolate(5%), Croscarmellose sodium(5%), Crospovidone (5%) respectively. The formulation prepared with 5%w/w of sodium starch glycolate was offered relatively rapid release of Ibuprofen when compared with other concentrations of Sodium Starch glycolate. The formulation prepared with Crospovidone was offered relatively rapid release of Ibuprofen when compared with other superdisintegrants. So, we can conclude that nature and concentration of the superdisintegrant showed influence on the rate of dissolution. The dissolution rate was found to follow first order kinetics.