V. Spandana, Siddartha
A simple, Accurate, precise method was developed for the simultaneous estimation of the Azelnipidine and Telmisartan in tablet dosage form. Chromatogram was run through standard symmetry C18 (4.6 × 150 mm, 5 mm). Mobile phase containing Buffer 0.01 N KH2PO4: Acetonitrile taken in the ratio 45:5 % v/v was pumped through column at a flow rate of 1 ml/min. Optimized wavelength selected was 290 nm. Retention time of Azelnipidine and Telmisartan were found to be 2.131 min and 2.593 min. % RSD of the Azelnipidine and Telmisartan were and found to be 0.8 and 0.6 respectively. % Recovery was obtained as 99.59 % and 99.94 % for Azelnipidine and Telmisartan respectively. LOD, LOQ values obtained from regression equations of Azelnipidine and Telmisartan were 0.86, 2.60 and 0.09, 0.29 respectively. Regression equation of Azelnidipine is Y =12533X+10387 and Y=9061X+183.8 of Telmisartan. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.