Abstrato

The master of regeneration-construction of pREMT

Yi Wang

Aristotle first described the regenerative functional phenotype in ancient Greece in 350 BC. Nowadays, typical organ regeneration cases are widely studied in all species. Endogenous molecular network theory combined
with the morphogen theory to construct the posterior regenerated endogenous network as a classification basis for the existence of regeneration function, and first classified the regeneration phenotypes of different species. We found that the liver regeneration function in rats is performed through a posterior regeneration endogenous network (posterior endogenous molecular network, pREMT), while the limb regeneration mode of Salamandridae is more likely to conform to the posterior regeneration mode than the anterior regeneration mode, which needs to be proven by further functional tests. A series of combinations of dynamic trends of key genes were obtained by randomly perturbing the pREMT and confirmed by comparison with biological "wet experiment" data， which can be used to guide induced liver regeneration in mammals such as humans. Our model predicts the possible functional features of some molecules: different Wnt homologs are likely to perform differentiated functions separately during posterior regeneration; high expression of APC and GJP is important for anterior regeneration, and high expression of hedgehog is important for both anterior and posterior regeneration.

This experiment uses the theory of regenerative endogenous molecular network–uses the topological network constructed by it to be insensitive to kinetic parameters–combines with the theory of form in to simplify the complex regenerative functional regulatory network.

Pointing out the existence of the analogues of "regenerative endogenous network" across Metazoan, let me re– understand the origin of regenerative function in the biological community, and provide a theoretical basis for human induced organ regeneration using other regenerative mode biomolecular regulatory mechanisms answered a question that has long plagued humans: What controls the regeneration of organisms?-Is "regenerative endogenous network ".