Abdulkadir Yusif Maigoro
Rheumatoid arthritis is an autoimmune disease and also a member of arthritis that can cause joint pain and damage in the body. The pathogenicity of (RA) is not fully elucidated due to its complexity but based on the available data interplay between environmental and genetic factor was reported. Therefore this Review is going to highlight the molecular pathways activated through the influence of Hypoxia inducible factor one alpha (HIF-1alpha) in (RA) and how these pathways might interact with inflammatory signaling, angiogenesis, as well as cartilage destruction via activation of some relevant genes in RA. In conclusion, this review highlighted the role of HIF-1alpha in pathogenesis of RA
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