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Tooth Whitening Efficacy of a Dentifrice Containing Papain and Bromelain Extracts: An In Vivo Clinical Study.

Ananthakrishna S, Raghu TN, Shankar S, and Soumya Shree BV

To study the effectiveness of a new dentifrice containing papain and bromelain extracts at whitening the tooth shade over a period of 3 weeks.A randomized, single center, pilot clinical study was designed to evaluate the effectiveness of a new dentifrice at whitening the tooth shade over a 3 week period .Thirty five subjects were included in the study.Each subject was assigned to the toothpaste. Subjects were instructed to brush twice daily with the supplied toothpaste & tooth brush. The subjects were recalled after 1 week, 2 weeks and 3 weeks and the tooth shade was examined using a Vita shade guide.Thirty four subjects completed the study. One subject did not complete the study because of personal or medical reasons unrelated to use of study toothpaste. The below tables indicates that the test dentifrice resulted in whitening the tooth shade over a period of 3 weeks.The test dentifrice showed significant whitening of tooth shade which could be attributed to the role of proteolytic enzymes in the test dentifrice.